Which medication class is contraindicated in heart failure due to risk of fluid retention?

Which medication class is contraindicated in heart failure due to risk of fluid retention?

• A. ACE inhibitors
• B. NSAIDs
• C. Loop diuretics
• D. Beta blockers

Answer: (B)

NSAIDs promote fluid retention in heart failure by diminishing kidney perfusion. In heart failure, the kidneys rely on prostaglandins to dilate the afferent arteriole and maintain glomerular filtration. NSAIDs inhibit prostaglandin synthesis, which reduces renal blood flow and GFR, leading to sodium and water retention and edema. This can worsen heart failure and trigger decompensation. Because of this, NSAIDs are avoided in heart failure. Other HF therapies like ACE inhibitors, loop diuretics, and beta blockers help by reducing fluid overload, preload, afterload, and remodeling, which is why they’re preferred in managing heart failure.

NSAIDs promote fluid retention in heart failure by diminishing kidney perfusion. In heart failure, the kidneys rely on prostaglandins to dilate the afferent arteriole and maintain glomerular filtration. NSAIDs inhibit prostaglandin synthesis, which reduces renal blood flow and GFR, leading to sodium and water retention and edema. This can worsen heart failure and trigger decompensation. Because of this, NSAIDs are avoided in heart failure. Other HF therapies like ACE inhibitors, loop diuretics, and beta blockers help by reducing fluid overload, preload, afterload, and remodeling, which is why they’re preferred in managing heart failure.