TZDs worsen what condition?

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Multiple Choice

TZDs worsen what condition?

Explanation:
Thiazolidinediones improve insulin sensitivity by activating PPAR-γ, but they cause fluid retention, leading to expanded plasma volume. This can precipitate or worsen congestive heart failure, which is why these drugs can worsen heart failure. They typically don’t worsen hyperglycemia (they actually help lower it) and aren’t primarily known for causing hypertension or renal failure. So the condition most worsened by TZDs is heart failure.

Thiazolidinediones improve insulin sensitivity by activating PPAR-γ, but they cause fluid retention, leading to expanded plasma volume. This can precipitate or worsen congestive heart failure, which is why these drugs can worsen heart failure. They typically don’t worsen hyperglycemia (they actually help lower it) and aren’t primarily known for causing hypertension or renal failure. So the condition most worsened by TZDs is heart failure.

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