NSAIDs should be avoided in patients with nasal polyps because

NSAIDs should be avoided in patients with nasal polyps because

• A. They can trigger aspirin-exacerbated respiratory disease
• B. They shrink nasal polyps
• C. They cure polyps
• D. They have no effect

Answer: (A)

NSAIDs are avoided in patients with nasal polyps because they can trigger aspirin-exacerbated respiratory disease. In this condition, people with asthma and nasal polyps have sensitivity to aspirin and other NSAIDs. Blocking COX-1 shifts arachidonic acid metabolism toward excess leukotriene production, which drives bronchoconstriction, nasal mucosal swelling, and increased mucus. This can lead to sudden worsening of breathing and nasal obstruction. Because of this risk, alternative pain relievers like acetaminophen are often preferred, and any NSAID use should be carefully avoided or managed under medical supervision if necessary.

NSAIDs are avoided in patients with nasal polyps because they can trigger aspirin-exacerbated respiratory disease. In this condition, people with asthma and nasal polyps have sensitivity to aspirin and other NSAIDs. Blocking COX-1 shifts arachidonic acid metabolism toward excess leukotriene production, which drives bronchoconstriction, nasal mucosal swelling, and increased mucus. This can lead to sudden worsening of breathing and nasal obstruction. Because of this risk, alternative pain relievers like acetaminophen are often preferred, and any NSAID use should be carefully avoided or managed under medical supervision if necessary.